Abstract

Papers of Harvey Itano, American biochemist and pioneer in the study of sickle cell anemia hematology. The collection documents Itano's research on sickle cell anemia disease and his work in the field of molecular medicine focusing on understanding of genetic and molecular basis of blood pathologies and hereditary diseases. The papers contains Itano's research and writings, reprints of his publications in scientific journals, and laboratory notebooks. Of special interest are notebooks documenting his electrophoresis experiments that led to the discovery of difference in electrophoretic mobility between normal and sickle cell hemoglobins and allowed him to explain the cause of the disease on a molecular basis. Also included is his professional correspondence with colleagues in the field of molecular medicine, especially letters from Linus Pauling dating from 1946 to 1986. The papers are arranged in five series: 1) MISCELLANEOUS MATERIALS, 2) CORRESPONDENCE, 3) NOTEBOOKS, 4) WRITINGS BY ITANO, and 5) LINUS PAULING -- MISCELLANEOUS MATERIALS.

Biography

Harvey Akio Itano was born on November 3, 1920, in Sacramento, California, the eldest son of Masao and Sumako (Nakahara) Itano. Itano attended University of California, Berkeley, and graduated in 1942 with highest honors in chemistry. Due to President Roosevelt's anti-Japanese campaign following Pearl Harbor, Itano with his family was sent to the desolate Tule Lake camp. While in the camp, Itano kept applying to medical schools throughout the country. With assistance from the National Japanese American Student Relocation Council, Itano was released from the camp to attend St. Louis School of Medicine. In 1945, Itano received his M.D. and continued Ph.D. studies at the California Institute of Technology in biochemistry where he studied and worked with Linus Pauling.

Itano is known for his pioneering work with sickle cell anemia disease, the topic assigned to him as a Ph.D. thesis topic by Linus Pauling. Sickle cell anemia disease is a hereditary disease commonly found among people of African descent. Itano tried several different physical and chemical methods to distinguish normal hemoglobin from sickle cell hemoglobin and finally he was able to demonstrate the difference by using electrophoresis. At that time, electrophoresis was a new technique that allowed researchers to separate molecules according to their electrical charge and Itano found a slight difference in electrophoretic mobility between normal and sickle cell hemoglobins. That led to understanding that patients with sickle cell anemia have a different type of hemoglobin than healthy individuals and thus a cause of a disease was traced to a molecule. Later, this inspired Vernon Ingram's seminal discovery of a single amino acid difference between normal and sickle cell hemoglobin and allowed him to explain a hemoglobin abnormality by an alteration in genes. After completing the project, Itano continued to work in the field of molecular medicine and published extensively about genetic and molecular basis of other blood pathologies and hereditary diseases.

Itano was awarded Eli Lilly Award in Biological Chemistry (1954) and Martin Luther King Jr. Medical Achievement Award (1972) for his pioneering work on sickle cell anemia disease. He is a member of the National Academy of Sciences (1979), American Academy of Arts and Sciences (1998), American Society of Biochemistry and Molecular Biology, Biochemistry Society (London), Phi Beta Kappa, Sigma Xi, and Alpha Omega Alpha.

Itano is professor emeritus in the Department of Pathology at UCSD and resides in La Jolla, California.

Scope and Content

The papers of Harvey Itano, an American biochemist, document his pioneering research on sickle cell anemia and his work in the field of molecular medicine focusing on understanding of genetic and molecular basis of blood pathologies and hereditary diseases. Well represented in the papers are his laboratory notebooks and reprints of his journal publications. Of special interest are notebooks documenting his electrophoresis experiments that led to the discovery of a slight difference in electrophoretic mobility between normal and sickle cell hemoglobins and allowed him to explain the cause of the disease on a molecular basis. Also included are correspondence files with his colleagues in the field of molecular medicine, especially letters from Linus Pauling dating from 1946 to 1986.

The papers are arranged in five series: 1) MISCELLANEOUS MATERIALS, 2) CORRESPONDENCE, 3) NOTEBOOKS, 4) WRITINGS BY ITANO, and 5) LINUS PAULING -- MISCELLANEOUS MATERIALS.

SERIES 1: MISCELLANEOUS MATERIALS

The MISCELLANEOUS MATERIALS series comprises materials providing biographical information and contains curriculum vitae with a list of publications, biographical forms, and articles mentioning Itano's work.

SERIES 2: CORRESPONDENCE

The CORRESPONDENCE series documents Itano's communication with colleagues in the field of molecular medicine. The materials are arranged in two subseries: A) Chronological Files and B) Alphabetical Files.

A) The Chronological Files (1969-1986) subseries primarily contains outgoing correspondence sent from Itano's office to his colleagues and professional journals.

B) The Alphabetical Files (1946-2000) subseries contains correspondence documenting Itano's election to the American Academy of Arts and Sciences and American Chemical Society, nomination to Martin Luther King Jr. Medical Achievement Award, letters from Linus Pauling, and correspondence with scholars who wrote about Pauling.

SERIES 3: NOTEBOOKS

The NOTEBOOKS subseries documents Itano's laboratory experiments and is arranged in five subseries: A) Composition Notebooks (1948-1986), B) Electrophoresis Experiments (1952-1953), C) Green Notebooks (1954-1969), D) Black Notebooks (1959-1976), and E) Brown Notebooks (1961-1962).

SERIES 4: WRITINGS BY ITANO

The WRITINGS BY ITANO subseries comprises of reprints of his journal publications. Also included is a copy of his Ph.D. dissertation and a few typescripts.

SERIES 5: LINUS PAULING -- MISCELLANEOUS MATERIALS

The LINUS PAULING -- MISCELLANEOUS MATERIALS contains announcements and broadsides of events dedicated to Linus Pauling and photocopies of newspaper and magazine articles discussing life and work of Pauling.

MISCELLANEOUS MATERIALS

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1 1 Biographical information. Contains curriculum vitae, supplementary biographical forms, biography submitted for WHO'S WHO IN AMERICA, and photocopies of articles discussing Itano's work.

CORRESPONDENCE

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Chronological Files

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1 2 1969-1971.
1 3 1972.
1 4 1973.
1 5 1974.
1 6 1975.
1 7 1976.
1 8 1977.
1 9 1978.
1 10 1979.
1 11 1980.
1 12 1981.
1 13 1982.
1 14 1983.
1 15 1984.
2 1 1985.
2 2 1986. January - April.
2 3 1986. May - December.

Alphabetical Files

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2 4 American Academy of Arts and Sciences, 1998.
2 5 American Chemical Society, 2000.
2 6 Bengelsdorf, Irving S., 1994.
2 7 Goertzel, Victor, 1980.
2 8 Heller, Paul, 1994.
2 9 Linus Pauling Festschrift Volume, 1966 - 1968.
2 10 Owen, Ray, 1994 - 1995.
2 11 Pauling Kamb, Linda, 1995.
2 12 Pauling, Linus, 1946 - 1966.
2 13 Pauling, Linus, 1969 - 1986.
2 14 Shellan, Jeffrey B., 1996.
2 15 Southern Christian Leadership Conference - Sickle Cell Anemia - Awards Banquet, 1972. Contains correspondence and biographical notes about Itano.
2 16 University of California, Berkeley - Berkeley Convocation - Japanese American Alumni Association, 1992.
2 17 Wills, Chris, 1997.
2 18 Zewail, Ahmed H., 1989 - 1990.

NOTEBOOKS

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Composition Notebooks, 1948 - 1986

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2 19 1948. Chemistry 259a.
3 1 1950 - 1952. Enzyme Kinetics, Physical Methods of Protein Chemistry.
3 2 1952 - 1954. 51 Crellin.
3 3 1972.
3 4 1972 - 1974.
3 5 1972 - 1974.
3 6 1973.
3 7 1973 - 1976.
3 8 1977.
4 1 1977 - 1979.
4 2 1979 - 1981.
4 3 1982 - 1986.

Electrophoresis Experiments, 1952 - 1953

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4 4 August 13, 1952 - January 27, 1953.
4 5 October 16, 1952 - January 13, 1953.
4 6 January 16 - June 26, 1953.
4 7 January 28 - May 15, 1953.
4 8 April 30 - June 10, 1953.
4 9 May 18 - July 27, 1953.
4 10 August 24 - August 27, 1953.
5 1 October 6, 1953.
5 2 October 7, 1953.

Green Notebooks, 1954 - 1969

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5 3 1954 - 1957.
5 4 1954 - 1967.
5 5 1955 - 1957.
5 6 1956 - 1958.
5 7 1958 - 1959.
6 1 1966.
6 2 1967.
6 3 1967 - 1968.
6 4 1969.
6 5 Undated.
7 1 Undated.

Black Notebooks, 1959 - 1976

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7 2 Black Laboratory Book, 1959 - 1961.
7 3 Black Laboratory Book, 1962 - 1964.
7 4 Black Laboratory Book, 1963 - 1965.
7 5 Black Laboratory Book, 1964 - 1966.
8 1 Black Laboratory Book, 1967.
8 2 Black Laboratory Book, 1967 - 1968.
8 3 Black Laboratory Book, 1972 - 1976.

Brown Notebooks, 1961 - 1962

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8 4 1961 - 1962.
8 5 1962.

WRITINGS BY ITANO

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8 6 Rapid Diagnostic Test For Sickle Cell Anemia, 1949. January. With Linus Pauling. Published in THE JOURNAL OF HEMATOLOGY, Vol. 14, No. 1. Contains reprint.
8 7 Sickle Cell Anemia, a Molecular Disease, 1949. November 25. With Linus Pauling, S.J. Singer and Ibert C. Wells. Contains a reprint and a photocopy of the republished paper in SELECTED PAPERS ON MOLECULAR GENETICS, edited by J. Herbert Taylor, 1965.
8 8 New Inherited Abnormality Of Human Hemoglobin, 1950. November. With James V. Neel. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.
8 9 Contributions To the Study Of Sickle Cell Hemoglobin, 1950. Ph.D. Thesis. Contains typescript.
8 10 Ratio Of Sickle Cell Anemia Hemoglobin To Normal Hemoglobin In Sicklemics, 1951. January. With Ibert C. Wells. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 188, No. 1. Contains typescript.
9 1 Familial Differences In the Proportion Of Abnormal Hemoglobin Present In the Sickle Cell Trait, 1951. October. With James V. Neel and Ibert C. Wells. Published in THE JOURNAL OF CLINICAL INVESTIGATIONS, Vol. XXX, No. 10. Contains reprint.
9 2 Notes On a Proposed Therapeutic Program For Sickle Cell Anemia, 1952. January, 21. Contains typescript.
9 3 Chronic Hemolytic Anemia Associated With Thalassemia and Sickling Traits, 1952. March. With Phillip Sturgeon and William N. Valentine. Published in THE JOURNAL OF HEMATOLOGY, Vol. VII, No. 3. Contains reprint.
9 4 Third Abnormal Hemoglobin Associated With Hereditary Hemolytic Anemia, 1951. December. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 37, No. 12. Contains reprint.
9 5 Hemolytic Anemia Presumably Due To Coexistence Of the Genes For Thalassemia and Sickling, 1952. With John S. Lawrence and James V. Neel. Published in TRANSACTIONS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, Vol. LXV. Contains reprint.
9 6 Human Hemoglobin, 1953. January, 30. Published in SCIENCE. Contains reprint.
9 7 Electrophoretic Studies Of Globins Prepared From Normal Adult and Sickel Cell Hemoglobins, 1953. February. With E. Havinga. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.
9 8 Qualitative and Quantitative Control Of Adult Hemoglobin Synthesis - A Multiple Allele Hypothesis, 1953. March. Published in AMERICAN JOURNAL OF HUMAN GENETICS, Vol. 5, No. 1. Contains reprint.
9 9 Two Cases Of Sickle Cell Disease Presumably Due to the Combination of the Genes For Thalassemia..., 1953. May. With James V. Neel and John S. Lawrence. Published in BLOOD, THE JOURNAL OF HEMATOLOGY, Vol. VIII, No. 5. Contains reprint.
9 10 Solubilities Of Naturally Occuring Mixtures Of Human Hemoglobin, 1953. November. Published in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 47, No. 1. Contains reprint.
9 11 Identification Of a Fourth Abnormal Human Hemoglobin, 1954. March 22. With W.R. Bergren and Phillip Sturgeon. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Contains reprint.
9 12 Zone Electrophoresis Of Abnormal Hemoglobins, 1954. With William R. Bergren and Phillip Sturgeon. Published in ACTA HAEMATOLOGICA. Contains reprint.
9 13 Clinical Manifestations Of Inherited Abnormal Hemoglobins, 1955. May. With Phillip Sturgeon and William R. Bergren. Published in THE JOURNAL OF HEMATOLOGY. Contains reprint.
9 14 Genetic and Biochemical Studies Of "Intermediate" Types Of Cooley's Anemia, 1955. July. With Phillip Sturgeon and William R. Bergren. Published in BRITISH JOURNAL OF HAEMATOLOGY, Vol. 1, No. 3. Contains reprint.
9 15 Clinical States Associated With Alterations Of the Hemoglobin Molecule, 1955. September. With Bethesda. Contains reprint.
9 16 Abnormal Human Hemoglobins, 1956. May 2. With William R. Bergren and Phillip Sturgeon. Published in MEDICINE, Vol. 35, No. 2. Contains reprint.
9 17 Hemoglobin J, 1956. May 18. With Oscar A. Thorup, Munsey Wheby and Byrd S. Leavell. Published in SCIENCE, Vol. 723, No. 3203. Contains reprint.
9 18 Hyposthenuria In Sickle Cell Anemia: A Reversible Renal Defect, 1956. September. With H.G. Keitel and D. Thompson. Published in THE JOURNAL OF CLINICAL INVESTIGATION, Vol. XXXV, No. 9. Contains reprint.
9 19 Demonstration Of Intermediate Forms Of Carbonmonoxy and Ferrihemoglobin..., 1956. November. With Elizabeth Robinson. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Contains reprint.
9 20 Hemoglobins, 1956. Published in ANNUAL REVIEW OF BIOCHEMISTRY, Vol. 25. Contains reprint.
9 21 Hemoglobin Intermediates, 1957. March. With Elizabeth Robinson. Published in FEDERATION PROCEEDINGS, Vol. 16, No.1. Contains reprint.
9 22 Electrophoretic Analyses Of the Abnormal Human Hemoglobins, 1957. May 2 - 3. Published in the PROCEEDINGS OF THE CONFERENCE ON HEMOGLOBIN. Contains reprint.
9 23 Interpretation Of Electrophoretic, Solubility and Denaturation Data In the Study Of Hemoglobin Differences, 1957. September. Published in FEDERATION PROCEEDINGS, Vol. 16, No. 3. Contains reprint.
9 24 Abnormal Hemoglobin Molecules In Relation To Disease, 1957. With Linus Pauling. Published in SATRYK URSVENSK KEMISK TIDSKRIFT. No. 69. Contains reprint.
9 25 Human Hemoglobins: Their Properties and Genetic Control, 1957. Published in ADVANCES IN PROTEIN CHEMISTRY, Vol. XII. Contains reprint.
9 26 Specificity In the Interaction Of Sickle Cell Hemoglobin Molecules, 1957. Published in MOLECULAR STRUCTURE AND BIOLOGICAL SPECIFICITY; Pub. No. 2. Contains reprint.
9 27 On Dissociation and Recombination Of Human Adult Hemoglobins A, S and C, 1958. June. With S. J. Singer. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.
9 28 On the Asymmetrical Dissociation Of Human Hemoglobin, 1958. December 16. With S. J. Singer. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 45, No. 2. Contains reprint.
9 29 Electrophoretic Separation Of Intermediate Compounds In Two Reactions Of Ferrihemoglobin, 1958. With E. Robinson. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 29. Contains reprint.
9 30 Constituents Of Human Hemoglobin, 1959. June 27. With E. Robinson. Published in NATURE, Vol. 183. Contains reprint.
9 31 Formation Of Normal and Doubly Abnormal Hemoglobins By Recombination Of Hemoglobin I With S and Cb, 1959. June 27. Published in NATURE, Vol. 183. Contains reprint.
9 32 Properties and Inheritance Of Hemoglobin By Asymmetrical Recombination, 1959. November 7. With E. Robinson. Published in NATURE, Vol. 184. Contains reprint.
9 33 Chemical and Genetical Units Of the Hemoglobin Molecule, 1959. With S. J. Singer and E. Robinson. Published in the Proceedings of Ciba Foundation Symposium on Biochemistry of Human Genetics. Contains typescript.
9 34 Asymmetrical Recombination Of Alkali - Dissociated Hemoglobin Mixtures, 1959. February 20. With E. Robinson. Published in NATURE, Vol. 185, No. 4712. Contains reprint.
9 35 Specific Recombination Of the Subunits Of Hemoglobin, 1960. August 31. With E. Robinson. Published in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol. 88. Contains reprint.
9 36 Genetic Control Of the Polypeptide Chains Of Hemoglobin, 1960. September 4 - 10. With E. A. Robinson. Published in the Proceedings of the VIIth International Congress of Hematology, held in Tokyo, Japan. Contains reprint.
9 37 Genetic Control Of the Alpha and Beta Chains Of Hemoglobin, 1960. November. With Elizabeth A. Robinson. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 46, No. 11. Contains reprint.
9 38 Identification Of the Recombinant Products Of Canine and Human Hemoglobins, 1960. December 3. With E. A. Robinson. Published in NATURE, Vol. 188, No. 4753. Contains reprint.
9 39 Thalassemia and the Abnormal Human Hemoglobins, 1961. July 22. With Linus Pauling. Published in NATURE, Vol. 191, No. 4786. Contains reprint.
9 40 Evidence For Coordination Of Monophenyl With Heme Proteins, 1961. With E. A. Robinson. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 83, No. 3339. Contains reprint.
9 41 Blocking Of Tryptic Cleavage Of Arginyl Bonds By the Chemical Modification Of the Guanido Group With Benzil, 1963. With A. J. Gottlieb. Published in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 12, No. 5. Contains reprint.
9 42 Dissociation and Association Of Hemoglobin Subunits, 1964. With E. A. Robinson and A. J. Gottlieb. Published in SUBUNIT STRUCTURE OF PROTEINS BIOCHEMICAL AND PHYSICAL ASPECTS. Contains reprint.
9 43 Chemical Modification Of Arginine With 1, 2 - Cyclohexanedione, 1965. August. With Koji Toi, Edward Bynum and Elaine Norris. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 240, No. 8. Contains reprint.
9 44 Synthesis and Structure Of Normal and Abnormal Hemoglobins, 1965. From the National Institute of Arthritis and Metabolic Disease. Contains typescript, draft and reprint.
9 45 Genetic Regulation Of Peptide Synthesis In Hemoglobins, 1965. June. Published in THE JOURNAL OF CELLULAR PHYSIOLOGY, Vol. 67, No. 3. Contains reprint.
9 46 Phenanthrenequinone As an Analytical Reagent For Arginine and Other Monosubstituted Guanidines, 1966. August. With Shigeki Yamada. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 130. Contains reprint.
9 47 Studies On the Chemical Modification Of Arginine, 1967. March 10. With Koji Toi, Edward Bynum and Elaine Norris. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 242, No. 5. Contains reprint.
9 48 Protein - Protein Interaction Among Hemoglobin Subunits, 1967. March. With A. J. Gottlieb and E. Robinson. Published in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 118, No. 3. Contains reprint.
9 49 Primary Structure Of Hopkins - I Haemoglobin, 1967. April. WIth A. J. Gottlieb and E. A. Robinson. Published in NATURE, Vol. 214, No. 5084. Contains reprint.
9 50 Chain Models Of 6.6 S and 3.9 S Mouse Myeloma Immunoglobulin Molecules, 1968. November. With T. Seki and E. Appella. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.
9 51 Structure - Rate Hypothesis and the Toll Bridge Analogy, 1968. Contains offprint.
9 52 Studies On the Quantitative Control Of Polypeptide Synthesis In Human Reticulocytes, 1968. With Haig H. Kazazian. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 243, No. 8. Contains reprint.
9 53 Comparitive Structures Of A Immunoglobins, 1969. June 1 - 7. With E. Apella, T. Seki and E. A. Robinson. Presented at a Symposium on Developmental Aspects of Antibody Formation and Structure at the National Institute of Health in Maryland. Contains reprint.
9 54 Introductory Speech For the Symposium On Metabolism Of Blood Pigment, 1960. September 4 - 10. Published in the Proceedings of the VIIIth International Congress of Hematology, held in Tokyo, Japan.
9 55 Phenyldiimide, Hemoglobin, and Heinz Bodies, 1970. October. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 67, No. 2. Contains reprint.
9 56 Moilar Extinction Coefficient Of Cyanmethemoglobin As Determined By Carbon Analysis, 1971. February. With W. M. Fogarty Jr. and W. C. Alford. Published in THE AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol. 55, No. 2. Contains reprint.
9 57 4 - Thialamine, a Strongly Basic Chemical Modification Of Cysteine, 1972. August 10. With Elizabeth A. Robinson. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 247, No. 15. Contains reprint.
9 58 2 - Aminophenantromidazole, Flourescent Product Of the Reaction Of Phenanthrenequinone, 1972. August. With Shigeki Yamada. Published in ANALYTICAL BIOCHEMISTRY, Vol. 48, No. 2. Contains reprint.
9 59 Methoanolysis Of the Pyrrolidone Of Amino - Terminal Pyroalutamic Acid In Model Peptides, 1972. August. Published in ANALYTICAL BIOCHEMISTRY, Vol. 48, No. 2. Contains reprint.
9 60 Stoichiometry Of the Oxidation Of Arylhydrazines With Ferricyanide, 1973. June. With S. Mannen. Published in TETRAHEDRON, Vol. 29. Contains reprint.
9 61 Delayed Removal Of N - Terminal Methionine From Nascent Global Chains In Sickle - Cell Anemia Reticulocytes, 1973. July. With Haruo Suzuki. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 70, No. 7. Contains reprint.
9 62 Quantitative Differences Between N - Terminal Methionyl Nascent Globin Chains Of Human and Rabbit Reticulocyte, 1973. November. Published in NATURE NEW BIOLOGY, Vol. 246, No. 152. Contains reprint.
9 63 Alkaline Condensation Of 9, 10 - Phenanthrenedione With N, N - Dialkyguandines, 1974. December. Published in THE JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 11. Contains reprint and two requests for reprints.
9 64 Absence Of Haemoglobin A In an Individual Simultaneously Heterozygous In the Genes For Hereditary.., 1974. With W. M. Fogarty Jr. and T. S. Vedvick. Published in THE BRITISH JOURNAL OF HAEMATOLOGY, Vol. 26. Contains reprint.
9 65 Effect Of Ring Substitution On the Hemolytic Action Of Arylhdrazines [38904], 1974. With David W. Hollister, William M. Fogarty, Jr. and Shigeyasu Mannen. Published in PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 147. Contains reprint.
9 66 Solubility Changes In Sickle Cell Hemoglobin As the Amino Groups are Carbamylated [38321], 1974. With T. S. Vedvick and H. M. Koenig. Published in the PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 147. Contains reprint.
9 67 Mechanism Of Induction Of HÅ“molytic Anaemia By Phenylhydrazine, 1975. August 21. Published in NATURE, Vol. 256, No. 5519. Contains reprint.
9 68 Deoxhemoglobin S : Solubility Vs. Erythrocyte Sickling, 1975. With T. S. Vedvick and H. M. Koenig. Published in CLINICAL BIOCHEMISTRY, Vol. 8. Contains reprint.
9 69 Induction Of Haemolytic Anaemia By Substituted Phenylhydrazines, 1975. With K. Hosokawa and K. Hirota. Published in THE BRITISH JOURNAL OF HAEMATOLOGY, Vol. 32, No. 99. Contains reprint.
9 70 Reactions Of Phenyldiazene and Ring - Substituted Phenyldiazenes With Ferrihemoglobin, 1975. With Shigeyasu Mannen. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 421. Contains reprint.
9 71 Topics In Hematology, 1976. September. Published in Excerpta Medica International Congress Series, No. 415. Contains reprint.
9 72 In Vitro Translation Of Globin: Effect Of Proteins Purified By Affinity Chromatography On Polyadenylate.., 1976. With Hiroichi Fukami. Published in BIOCHEMISTRY, Vol. 15, No. 3529. Contains reprint.
9 73 Mechanism and Specifity Of the Phenanthrenequinone Test for Monosubstituted Guanidines, 1976. With Kazuhiro Hirota, Ichiro Kawasaki and Shigeki Yamada. Published in ANALYTICAL BIOCHEMISTRY, Vol. 76. Contains reprint.
9 74 Partial Characterization Of the Hemoglobin From Hubb's Beaked Whale, 1976. With T. S. Vedvick. Published in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, Vol. 55B. Contains reprint.
9 75 Liglands and Oxidants In Ferrihemochrome Formation and Oxidative Hemolysis, 1977. June. With Kazuhiro Hirota and Thomas Vedvick. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 74, No. 6. Contains reprint and typescript of adresses.
9 76 Influence Of Ring Substitutes On the Binding Of Nitrosobenzene By Ferrohemoglobin, 1978. May. With Kazuhiro Hirota. Published in THE JOURNAL OF BIOCHEMISTRY, Vol. 253, No. 10. Contains reprint.
9 77 Oxidative Degradation Of Haemoglobin By Nitrosobenzene In the Erythrocyte, 1978. With Kazuhiro Hirota and Thomas S. Vedvick. Published in THE BIOCHEMISTRY JOURNAL, Vol. 174. Contains reprint.
9 78 Initiation Of Fetal Hemoglobin Biosynthesis, 1979. With Hitoshi Imanishi and Haruo Suzuki. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 564. Contains reprint.
9 79 Induction Of Anemia In Spelnectomized and Nonsplenectomized Rats, 1980. With Thomas S. Vedvick. Published in PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 163. Contains reprint.
9 80 Further Studies On the Chemical Modification Of Arginine. Undated. Contains one page typescript.
9 81 Genetic and Physical Factors In the Meterogeneity Of Hemoglobin. Undated. Contains reprint.
9 82 Interpretation Of Data On Haemoglobin Heterogeneity. Undated. Contains reprint.
9 83 Sensitive Test For Arginine and Other Guanido Compounds. Undated. Contains one page typescript.

LINUS PAULING -- MISCELLANEOUS MATERIALS

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10 1 Announcements and broadsides of events with participation of Linus Pauling or dedicated to him, 1946 - 1994.
10 2 Newspaper and magazine articles about Pauling, 1946 - 1998.



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