OFF-SITE STORAGE

COLLECTION STORED OFF-SITE: ALLOW ONE WEEK FOR RETRIEVAL OF MATERIALS

Access

In accordance with state and federal law, materials in Box 3, Folder 18 and Box 24, Folder 12 are restricted until 2067.

Abstract

Papers of Morris Friedkin, American biochemist, professor and university administrator. His research interests included folic acid metabolism, cancer chemotherapy, enzymology, DNA synthesis, biochemical dynamics of the cell cycle, pharmacology, and positron emission tomography. Materials include laboratory notebooks, loose notes, data, chemical and research product subject files; reprints and typescripts of published and unpublished writings by Friedkin; documents related to grants and fellowships; annotated writings by others; and correspondence. Also included are course materials and notes from Friedkin's time as student at Iowa State College and at University of Chicago; and teaching materials and administrative materials from his time as a faculty member and/or administrator at Washington University, Tufts University, and the University of California, San Diego.

Biography

Morris E. Friedkin was born on December 30, 1918, in Kansas City, Missouri. Upon finishing high school in 1936, he entered Kansas City Junior College and received an A.A. in chemistry in 1938. Friedkin continued his education at Iowa State College receiving a B.S. in chemistry in 1940 and an M.S. in analytical chemistry in 1941. After completing his master's degree, he enrolled in the doctorate program in biochemistry at the University of Chicago where he was one of the first graduate students of the renowned biochemist, Albert Lehninger. In 1948, Morris Friedkin completed his Ph.D. with the submission of his dissertation entitled "Studies on Aerobic Phosophorylation." After receiving his doctorate, he continued his studies for one year as a postdoctoral fellow of the National Institutes of Health at the University of Copenhagen.

Friedkin returned to the United States in 1949 and accepted a faculty position in the Department of Pharmacology at the Washington University School of Medicine. In 1957, he joined the faculty of the Department of Pharmacology at the Tufts University School of Medicine where he also served as chair of the department in addition to his teaching and research responsibilities. In 1969, looking to devote more time to research and less to administrative duties, he moved to the Department of Biology at the University of California, San Diego, School of Medicine. For the remainder of his professional career at UCSD except for a short appointment as provost of Revelle College (1974-1976), Friedkin focused exclusively on research and teaching.

Throughout his career, Friedkin worked in many different areas of biochemical research usually with the aim of developing chemotherapies for medicinal application. While attending the University of Chicago, he worked as chemist on the "Penicillin Project" at the Northern Regional Research Laboratory. In 1966, the United States Army contracted with Friedkin to explore new areas in the development of drugs for malaria-resistance. Also in the 1960s, he began his career-long study of cancer chemotherapy with particular interest in the treatment of leukemia. In the course of over forty years of scientific research, Friedkin's contributions advanced scientific understanding in many areas of biochemistry including folic acid metabolism, the biochemical basis of the cell cycle and cell growth, the use of radioactively labeled molecules in biochemical research, molecular pharmacology, DNA synthesis, the structure and function of microtubules, and positron emission tomography. He published regularly in scholarly journals throughout his career and was honored with membership to the National Academy of Sciences in 1978.

Morris Friedkin retired from his position in the Department of Biology at the University of California, San Diego School of Medicine in 1989. He died on September 19, 2002.

Scope and Content of Collection

The Morris E. Friedkin Papers document the professional career of the American biochemist whose research interests throughout his lifetime included folic acid metabolism, cancer chemotherapy, enzymology, DNA synthesis, the biochemical dynamics of the cell cycle and cell growth, pharmacology, the use of radioactively-labeled molecules in biochemical research, and positron emission tomography. Materials reflecting Friedkin's scientific activities include an extensive but incomplete set of laboratory notebooks, documents related to specific research projects, information Friedkin collected on specific chemicals and laboratory products, loose data, miscellaneous research notes, and descriptions of laboratory techniques. Other materials include documents related to Friedkin's grants and fellowships, correspondence, reprints and typescripts of Friedkin's writings, and manuscripts or typescripts of lectures about his research. Also included are notes and materials from courses Friedkin took as an undergraduate at Iowa State College and as a graduate student at the University of Chicago. Finally, the papers contain materials related to Friedkin's teaching and administrative duties at the Washington University School of Medicine, Tufts University School of Medicine, and the University of California, San Diego, School of Medicine. The papers are arranged in ten series: 1) BIOGRAPHICAL MATERIALS, 2) CORRESPONDENCE, 3) EDUCATION MATERIALS, 4) GRANTS AND FELLOWSHIPS, 5) RESEARCH MATERIALS, 6) WRITINGS BY FRIEDKIN, 7) TEACHING AND ADMINISTRATIVE MATERIALS, 8) WRITINGS BY OTHERS, 9) MISCELLANEOUS MATERIALS, and 10) ORIGINALS OF PRESERVATION PHOTOCOPIES.

SERIES 1: BIOGRAPHICAL MATERIALS

The BIOGRAPHICAL MATERIALS series, arranged alphabetically, contains materials documenting significant events in Friedkin's life such as his birth certificate, his doctoral diploma, materials regarding his sabbatical leaves, and two personal logs with regular entries.

SERIES 2: CORRESPONDENCE

The CORRESPONDENCE series is arranged in three subseries: A) Chronological Files, B) A to Z Files, and C) Letters of Recommendation.

A) The Chronological Files subseries is arranged chronologically. The order and content of these files remain unchanged from their original state except that letters of recommendation written for or by Friedkin were seperated and placed into their own folder in the Letters of Recommendation subseries.

B) The A to Z Files subseries, arranged alphabetically by correspondent, contains letters written to or from Friedkin from 1948 to 1987. Included is correspondence with the renowned biochemist and Friedkin's graduate advisor, Albert Lehninger.

C) The Letters of Recommendation subseries contains letters of recommendation, arranged chronologically, written by Friedkin for students, colleagues, and employees. Also included are letters of recommendation written for Friedkin.

SERIES 3: EDUCATION MATERIALS

The EDUCATION MATERIALS series is arranged in three subseries: A) Iowa State College, B) University of Chicago, and C) Stanford University.

A) The Iowa State College subseries, arranged alphabetically, contains materials related to courses Friedkin attended at his undergraduate institution, Iowa State College, from 1939 to 1941. Materials include course notes, laboratory notes, written reports, and course handouts from courses in biochemistry, chemistry, colloid chemistry, and sanitary bacteriology.

B) The University of Chicago subseries, arranged alphabetically, contains materials related to courses Friedkin attended at his graduate institution, the University of Chicago, from 1942 to 1948. Materials include course notes and notebooks, laboratory notes and notebooks, course handout, written assignments, and copies of examinations from courses in biochemistry and genetics.

C) The Stanford University subseries, arranged alphabetically, contains materials from a course in microbiology Friedkin took at Stanford University in 1956. Materials include course notes and notebooks, a poster of microrganisms, and course handouts.

SERIES 4: GRANTS AND FELLOWSHIPS

The GRANTS AND FELLOWSHIPS series is arranged in two subseries: A) New Antagonists of Amethopterin-Resistant Leukemia and B) Miscellaneous.

A) The New Antagonists of Amethopterin-Resistant Leukemia subseries, arranged chronologically, contains documents related to Friedkin's longest continuous grant from the Department of Health, Education and Public Welfare at the National Institutes of Health for the funding of a project entitled "New Antagonists of Amethopterin-Resistant Leukemia" from 1968 to 1985. Included are grant applications, correspondence, notices of research projects, progress reports, project evaluations, and documents related to Friedkin's subcontracting of SRI International.

B) The Miscellaneous subseries, arranged chronologically, contains materials related to Friedkin's other grants and fellowships. Materials include applications, correspondence, and miscellaneous records from Friedkin's United States Public Health Service postdoctoral fellowship at the University of Copenhagen in 1948 to his application to the University of California, San Diego, for funding of a project entitled "Synthesis of Difluoromethylornithine" in 1988.

SERIES 5: RESEARCH MATERIALS

The RESEARCH MATERIALS series is arranged in four subseries: A) Laboratory Notebooks and Notes, B) Projects, C) Chemical and Product Information, and D) Data and Laboratory Techniques.

A) The Laboratory Notebooks and Notes subseries, arranged alphabetically, contains laboratory notebooks and loose research notes from the 1940s to the 1980s. Included are loose notes from short periods during which Friedkin worked at the Brookhaven National Laboratory in the 1950s, 1960s, and 1980s. Also included are laboratory notebooks which Friedkin numbered from the period of his dissertation research at the University of Chicago in the late 1940s to the period of his research at the University of California, San Diego, in the late 1970s. Although the labels on the notebooks are numerically discontinuous, the content of the notebooks are continuous chronologically from 1946 to 1973. Also included are a few unnumbered laboratory notebooks and a folder of miscellaneous research notes.

B) The Projects subseries, arranged alphabetically, contains materials related to specific research projects from 1968 to 1988. Materials include loose research notes, data, graphs, writings by others, and photographs or other illustrations for projects on phosophoserine, cell proliferation, colchine, DNA, folic acid, microtubules, a possible leukemia inhibitor, and thymidylate synthetase.

C) The Chemical and Product Information subseries, arranged alphabetically, contains materials collected by Friedkin concerning chemicals or laboratory products of interest and possibly used in his research. Included are writings by others annotated by Friedkin, notes, and product pamphlets.

D) The Data and Laboratory Techniques subseries, arranged alphabetically, contains materials which are not related to any of the materials in the other RESEARCH MATERIALS subseries. Included are data collected by Friedkin's students and research assistants, data from specific experiments, annotated writings by others on laboratory techniques, and typescripts of laboratory protocols.

SERIES 6: WRITINGS BY FRIEDKIN

The WRITINGS BY FRIEDKIN series is arranged in three subseries: A) Numbered Publications, B) Lectures, and C) Unnumbered Publications and Unpublished Writings.

A) The Numbered Publications subseries, arranged chronologically, contains reprints, typescript drafts, and drafts of figures for writings published by Friedkin in professional and scholarly journals from 1945 to 1985. Included is a publication list from the collection that lists Friedkin's publications chronologically and numbers them from 1 to 122. The set of numbered publications is incomplete.

B) The Lectures subseries, arranged chronologically, contains materials from lectures Friedkin gave on various biochemical topics at professional conferences or at other universities. Included are miscellaneous lecture announcements and manuscripts or typescripts of his lectures.

C) The Unnumbered Publications and Unpublished Writings subseries, arranged alphabetically, contains reprints or photocopies of published articles that are not on the numbered publication list, manuscripts or typescripts of papers reviewed but not accepted for publication, a typescript copy of Friedkin's dissertation, and other miscellaneous writings.

SERIES 7: TEACHING AND ADMINISTRATIVE MATERIALS

The TEACHING AND ADMINISTRATIVE MATERIALS series is arranged in three subseries: A) Washington University School of Medicine, B) Tufts University School of Medicine, and C) UCSD School of Medicine.

A) The Washington University School of Medicine subseries, arranged chronologically, contains mostly course handouts and manuscripts or tyepscripts of lectures for biochemistry or statistics courses taught by Friedkin. Included are photographs of some of the research facilities at Washington University. Both the teaching and administrative materials are arranged chronologically, but they are not interfiled. The teaching materials, arranged chronologically, appear first and any administrative materials follow, also arranged chronologically.

B) The Tufts University School of Medicine subseries, arranged chronologically, contains both teaching and administrative materials. Included are Tufts University School of Medicine yearbooks, a bound collection of articles produced by the faculty of the Department of Biochemistry during Friedkin's time as chair of the department, newspaper clippings, miscellaneous administrative materials, and two folders of miscellaneous laboratory floorplans. Also included are course handouts and typescripts of lectures for courses Freidkin taught at Tufts. Teaching materials, arranged chronologically, appear first in the subseries while any administrative materials, arranged chronologically, follow the teaching materials. The two groups of materials are not interfiled within the subseries.

C) The UCSD School of Medicine subseries is arranged in the same manner as the previous two subseries with the teaching materials, arranged chronologically, followed by the administrative materials, also arranged chronologically. Included are course handouts and lecture manuscripts for biochemistry courses Friedkin taught in the 1970s. Also included are materials related to Friedkin's work as provost of Revelle College (1974-1976), and a restricted file of documents related to Friedkin's role as an investigator of a complaint of scientific misconduct.

SERIES 8: WRITINGS BY OTHERS

The WRITINGS BY OTHERS series, arranged alphabetically, contains reprints or typescripts of articles on biochemistry or related topics, many with notations, collected by Friedkin.

SERIES 9: MISCELLANEOUS MATERIALS

The MISCELLANEOUS MATERIALS series, arranged alphabetically, contains materials unrelated to any other series in the collection. Included are materials documenting Friedkin's attendance at various professional conferences, miscellaneous slides presumably related to Friedkin's lectures, letters Friedkin wrote to politicians concerning the war in Vietnam, newspaper clippings, and documents related to Friedkin's review of the graduate pharmacology program at the University of California, San Francisco.

SERIES 10: ORIGINALS OF PRESERVATION PHOTOCOPIES

The ORIGINALS OF PRESERVATION PHOTOCOPIES series contains the originals of brittle or high acid content documents that have been photocopied.

BIOGRAPHICAL MATERIALS

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1 1 Curriculum vitae, undated.
1 2 Diploma - University of Chicago, 1948.
1 3 Employment materials - United States Department of Agriculture and University of Chicago, 1941 - 1946.
1 4 Kaiser-Permenente Excellence in Teaching Award, 1981 - 1982.
1 5 Letters of Certification from the Iowa State College Registrar, 1940 - 1946.
1 6 Newspaper clippings mentioning Friedkin, 1965 - 1975.
Personal logs.
1 7 Notebook containing autobiographical, travel, and lecture notes from the period when Friedkin was at the University of Copenhagen, 1948 - 1949.
1 8 Notebook containing some research related notes but primarily autobiographical journal entries, 1957 - 1989.
1 9 Photograph - Friedkin in front of Geisel Library.
1 10 Sabbatic leaves - Program statements, sabbatical leave reports and correspondence, 1972 - 1988.
1 11 Transcript of birth record, 1919.

CORRESPONDENCE

Chronological Files

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1 12-16 1951 - 1955.
2 1-2 1956 - 1957.
2 3-8 1982 - 1987.

A to Z Files

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2 9 A to L - Miscellaneous, 1948 - 1987.
2 10 M to Z - Miscellaneous, 1948 - 1985.
2 11 Baer, Ed, 1979.
2 12 Bertino, Joseph R., 1963 - 1989.
2 13 Bishop, George - Includes article manuscripts and glass slides, 1958 - 1961.
2 14 Brandt, Sven, 1948.
2 15 Brunsletter, Byron C., 1948.
2 16 Gates, Betsy Jane, 1978 - 1979.
2 17 Grossowicz, Nathan, 1980 - 1982.
2 18 Hoffman-LaRoche Inc., 1979 - 1981.
Correspondents: Alan F. Cook, Michael Drzyzga and W. E. Scott.
2 19 Huennekens, Frank M., 1965 - 1967.
2 20 Kalckar, Herman M., 1948 - 1978.
2 21 Koppelman, Ray, 1963 - 1964.
Correspondence with Abel Hoffman is stapled to some of the Koppelman letters.
2 22 Kornberg, Arthur, 1959 - 1977.
2 23 Lederle Laboratories, 1961 - 1963.
Correspondents: Robert B. Angier and E. L. Robert Stokstad.
2 24 Lehninger, Albert L., 1949 - 1985.
2 25 Lindsley, Dan, 1978 - 1979.
2 26 Livingston, David, 1969 - 1982.
3 1 Lowry, Oliver H., 1949 - 1989.
3 2 Maloney, William F., 1966 - 1968.
3 3 Mathews, Christopher K., 1963 - 1965.
3 4 McQuade, Henry, 1958 - 1975.
3 5 National Institutes of Health, 1952 - 1984.
Correspondents: E. P. Cronkite, Irvin Fuhr, Abraham Goldin, Dwijendra K. Misra, Moreshwar Nadkarni, Mary V. Niemic, Kenneth Paull, Frederick Stohlmann, and C. Gordon Zubrod.
3 6 Plante, Larry, 1988.
3 7 Plowman, Jacqueline, 1984.
3 8 Rizack, Martin A., 1959 - 1960.
3 9 Roche Products Limited, 1983.
Correspondents: Frank R. Atherton, C. H. Hassall and N. R. Rogers.
3 10 Rozengurt, Henry (Enrique), 1979 - 1982.
3 11 Schwarz Laboratories Inc., 1959.
3 12 Silber, Robert, 1962 - 1963.
3 13 Singer, S. Jonathan, 1964.
3 14 Sprinson, David B., 1959.
3 15 Stone, Frederick L., 1948 - 1949.
3 16 Strominger, Jack, 1961 - 1962.
3 17 Unidentified correspondents.

Letters of Recommendation

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3 18 Letters of recommendation, 1953 - 1987.
Restrictions Apply

COLLEGE MATERIALS

Iowa State College

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3 19 Biochemistry 301, 1941.
3 20 Biochemistry, untitled - Course notes, 1941.
3 21 Chemistry 512 - Course notes and lab materials, 1941.
3 22 Chemistry 519, Microquant - Course notes, 1941.
3 23 Chemistry 531 - Course notes, ca. 1941.
3 24 Colloid Chemistry - Course handouts and notes, 1939.
3 25 Sanitary Bacteriology - Course notes, typescript drafts of assignments and handouts, 1940.

University of Chicago

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4 1 Biochemistry 201 - Course handouts and examinations, 1945 - 1946.
4 2-3 Biochemistry 202 - Course handouts, lab materials, notebook, and examinations, 1945 - 1948.
4 4-6 Biochemistry 305 - Course handouts, notebooks, notes and examinations, 1942 - 1948.
4 7-8 Biochemistry 306 - Course notes, handouts, notebook, and examinations, 1946.
Genetics 211.
4 9 Course notes, handouts and written assignments, 1945.
4 10 The Unity of Genetics and Biochemistry in Phenylpyruvic Oligophrenia - Typescript, 1945.
4 11 Unidentified course notes, 1950.

Stanford University

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Introduction to Microbiology.
4 12 Course description and notes, 1956.
4 13 FB-282-09 Poster, 1956.
5 1-2 Spiral notebooks, 1956.

GRANTS AND FELLOWSHIPS

New Antagonists of Amethopterin-Resistant Leukemia

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5 3 Progress Reports, 1963 - 1987.
5 4 Correspondence, 1968 - 1987.
5 5 Grant Applications, 1968 - 1984.
5 6 Grant Applications Appendices, 1968 - 1984.
5 7 Notices of Grant Awarded, 1969 - 1985.
6 1 Applications for Continuation Grant, 1970 - 1985.
6 2 Notices of Research Project, 1976 - 1982.
6 3 Project Evaluations, 1977 - 1985.
6 4 SRI International - Project proposal and correspondence, 1980 - 1984.

Miscellaneous

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6 5 United States Public Health Service Fellowship - Application, correspondence and progress report, 1948.
6 6 Graduate Training Grant - Applications, progress reports, correspondence, and Tufts University pharmacology graduate program guide, 1960 - 1968.
6 7 Design of New Antifolates for Use in Drug-Resistant Malaria - Application, progress reports, photographs, and related article reprints, 1961 - 1967.
Biochemistry of the Transition from Quiescence to Replicative Growth in the Cell Cycle...
6 8 Guggenheim Fellowship - Application, notes, pamphlets, and correspondence, 1972 - 1978.
6 9 Eleanor-Roosevelt International Cancer Fellowship - Application, notes, correspondence, and progress reports, 1977 - 1979.
6 10 Macy Faculty Scholar Award - Application, notes and correspondence, 1978.
6 11 Role of Cytoplasmic Microtubules in the Regulation of the Activity of Peptide Growth Factors - Applications to the National Science Foundation and American Cancer Society, 1981 - 1983.
6 12 Effects of Amino Acid Phosphonate (APBA) on the Growth of Mouse Leukemic Cells - Application and correspondence, 1984.
6 13 Effects of 2-Amino-4-Phosphono-Butyric Acid on the Growth of L1210 Murine Leukemia Cells from Exponential... - Applications, applications for continuation grant and correspondence, 1985.
6 14 Inhibitory Effects of Phosphono Amino Acids on the G0/G1 Period of Leukemia Cells - Application and correspondence, 1985 - 1988.
6 15 Inhibition of Leukemia Cells by Phosphono Amino Acids - Applications and correspondence, 1985 - 1988.
6 16 Isolation and Identification of CERDLIN (Cation Exchange Resin Derived Leukemia Inhibitor) - Applications, 1986.
6 17 Synthesis of Difluoromethylornithine - Application and notes, 1988.

RESEARCH MATERIALS

Laboratory Notebooks and Notes

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7 1 Research notes - Miscellaneous, 1959 - 1988.
Brookhaven National Laboratory.
7 2 1957.
7 3 1960 - 1961.
7 4 1962. Sodium Borohydride Tritium Experiments - Notebook, graphs, data tables, and photocopies of writings by others.
7 5 1962 - 1972. Carbon Eleven.
7 6 1986 - 1988.
7 7 Computer notes, 1961.
7 8 Experiments 1 to 186, 1978 - 1979.
8 1 Experiments 373 to 536, 1980 - 1981.
8 2 Experiments 537 to 834, 1981 - 1985.
8 3 Experiments 835 to 1159, 1985 - 1987.
9 1 Metabolic Scenarios I, 1983.
9 2 Methods - Tissue Culture Techniques, 1980 - 1981.
9 3 Northern Regional Research Laboratory - Research notes, ca. 1941 - 1945.
9 4-5 Notebooks, 1986 - 1988.
University of Chicago.
9 6 Notebooks 1 - 2, 1946 - 1947.
10 1-2 Notebooks 3 - 6, 1947.
10 3-4 University of Chicago and University of Copenhagen. Notebooks 7 - 10, 1948 - 1949.
10 5-6 University of Copenhagen. Notebooks 11 - 12, 1949.
Washington University.
11 1-2 Notebooks 13 - 14, 1949 - 1951.
11 3-4 Notebooks 18 - 19, 1950 - 1952.
12 1-2 Notebooks 23 - 24, 1952 - 1953.
12 3 Notebook 27, 1953 - 1954.
12 4 Notebook 33, 1954 - 1955.
13 1-4 Notebooks 34 - 37, 1955 - 1957.
14 1 Notebook 42, 1957.
Tufts University.
14 2-3 Notebooks 43 & 45, 1957 - 1958.
14 4 Notebook 48, 1958 - 1959.
15 1 Notebook 57, 1959 - 1961.
15 2 Notebook 64, 1961 - 1964.
15 3 Notebook 74, 1963 - 1965.
15 4 Tufts University and University of California, San Diego. Notebook 84, 1965 - 1970.
16 1-2 University of California, San Diego. Notebooks 92 & 95, 1970 - 1978.
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Cation Exchange Resin Derived Leukemia Inhibitor (CERDLIN).
16 3 Data and graphs, 1987 - 1988.
16 4 Elemental analysis, ca. 1988.
16 5 FB-360-01 Infrared spectra - Oversize, ca. 1987.
16 6 FB-360-02 Oversize, 1987 - 1988.
16 7-8 FB-360-03 Cell Proliferation Project (L-glutamate, Sodium Butyrate, and Quisqualic Acid) - Data, notes and writings by others, 1982 - 1986.
17 1 Colchine Effects on [3H] Uridine and [3H] Thymidine - Data tables and graphs, 1981.
17 2 Colchine, unidentified data - Data tables, graphs and writings by others, 1968.
DNA Profiles.
17 3 Aminoethyl Phosphonate (AEP) Log Cells also Quisqualic Acid and 2-Amino-4-Phosophono-Butyric..., 1985.
17 4 BUdR Staining and Effect of Taurine, 1985.
17 5 Cytofluorometry (Judy Nordberg), 1985.
17 6 Effects of Aminoethyl Phosphonate (AEP), Quisqualic Acid (QQ), and HC (Elizabeth Crawford), 1985.
17 7 Experiment 908 - Effect of Quisqualic Acid on Cell Cycle of L1210, 1986.
17 8 PE, PC and Ethanolamine (Elizabeth Crawford), 1985.
17 9 Quisqualic Acid Experiment (Donna Ruthenmeyer), ca. 1985.
17 10 Sed 3 Experiment, 1985.
17 11 Folic Acid - Correspondence, data, graphs, notes, and protocols, 1961 - 1969.
17 12 Microtubule Theory of Memory - Notes and writings by others, 1974 - 1984.
Phosphoserine Project.
17 13 Correspondence - William Colwell, Jac L. Crase, Joe DeGraw, James D. Haug, Alton Meister, Charles H. Stanmer, and Yoshi Tsujita, 1982 - 1984.
17 14 Illustrations, undated.
17 15 Miscellaneous - Includes flyers for lectures, technical information of lab equipment and products and other materials, ca. 1978 - 1984.
17 16 Notes, 1978 - 1984.
17 17 Photographs, Ca. 1978 - 1984.
17 18 Starch Gel Electophoresis, undated.
17 19 Writings by others, 1955 - 1975.
17 20 Thymidylate Synthetase - Amino acid sequences, correspondence, notes, and writings by others, 1971 - 1986.

Chemical and Product Information

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18 1 A to Z - Miscellaneous Product Information, 1956 - 1987.
18 2 2-Amino-3-Phosphonopropionic Acid, 1964 - 1984.
18 3 3T3 Cells - Henry (Enrique) Rozengurt publications, 1975 - 1981.
18 4 Bakerbond Chiral Phase Columns - Correspondence, notes and product information, ca. 1984.
18 5 Chemical Library Search Results (American Cancer Society), 1988.
18 6 Chemical requests - Correspondence to or from Friedkin regarding the acquisition of chemicals for research projects, 1953 - 1983.
18 7 Difluoromethane-ornithine - Correspondence, notes and reprint, 1989.
18 8 Dystrophin, 1968 - 1988.
18 9 Fluoronucleotides, 1983 - 1985.
18 10 Hept-6-yne-2,5-diamine, 1983 - 1987.
18 11 Hydra-derived Inhibitors - Notes and photocopies of writings by others, 1983 - 1985.
18 12 Inhibitory Effects of Aminoethyl Phophonate (AEP) - Correspondence with A. F. Isbell, notes and photocopies of writings by others, 1959 - 1985.
18 13 IR and Molecular Ions - Mass spectra and mass chromatagrams, undated.
18 14 FB-360-04 Laboratory equipment lists - Oversize, 1988.
18 15 Liposomes, 1969 - 1986.
18 16 Ornithine Decarboxylase - Notes and reprints, 1974 - 1988.
18 17 Phthaloylamino Acids - Notes and photocopies of writings by others, 1972 - 1983.
18 18 Phosphonopeptides, 1978 - 1979.
19 1 Rubidium and Sodium Ions, 1975 - 1980.
19 2 Tulp Sedementation Chamber - Graphs, photocopies of writings by others and photographs with negatives, 1980 - 1985.

Data and Laboratory Techniques

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19 3 2-Amino-4-Phosphono-Butyric Acid (APBA) - Graphs for poster, undated.
19 4-5 FB-360-05 Aminophosphonocarboxylic Acid Compounds - Nuclear magnetic resonance spectra and correspondence with Jac L. Crase, 1983.
19 6 Crawford, Elizabeth, Last experiment - Data, graphs and notes, 1987.
19 7 Cronin, Maurin - Data, ca. 1985.
19 8 Diethyl APPA (John Wright) - Data and nuclear magnetic resonance spectra, 1979 - 1985.
19 9 Dimethyl Aminoethyl Phosphonate (AEP) Cyanoborohydride Products - Nuclear magnetic resonance spectra, 1986.
19 10 Experiments 1058, 1065, 1074, 1079,1098 and 1111 - Data, HPLC printouts and spectrographs, 1987.
19 11 Jackson, James - Notes and data, 1980 - 1981.
19 12 L1210 +/- BUDr +/- Aminoethyl Phosphonate (Elizabeth Crawford) - Data, graphs and notes, 1985.
19 13 Organic Synthesis - Notes and photocopies of writings by others, 1941 - 1987.
19 14 Organic Synthesis Techniques (Frank H. Stodola) - Notes and reprints of writings by others, 1942 - 1945.
19 15 Plante (Larry) Compounds - Summary, undated.
19 16 Positron Emission Tomography - Photocopies and reprints of writings by others, 1948 - 1987.
19 17 Procedure for Phosphate Determination, 1977.
19 18 Protocol for the Prepartion of 3T3 Cell Extracts, ca. 1979.
19 19 Proton Magnetic Resonance - Notes and photocopies of writings by others, 1975 - 1988.
19 20 Redistilled Water Room at the Washington University School of Medicine - Drawing and photograph of redistillation apparatus, 1958.
19 21 Resolution of Phosphono Compounds - Notes and photocopies of writings by others, 1979 - 1984.
19 22 Ruthemeyer, Donna - Data Summary, 1985.
19 23 Scintigraphy - Graphs, 1977.
19 24 Thiouracil Deoxyriboside Crystals, ca. 1954.
19 25 Use of Nuclear Magnetic Resonance Instrument at Brookhaven National Laboratory - Notes, 1987.
19 26 X-ray Diffraction of Synthetic and Natural Thymidine - Data and x-ray images, 1953.
19 27 Unidentified research images - Photographs and glass slide from Washington University Department of Illustrations, undated.
20 1 Unidentified research materials - Chromatographs and x-ray films, 1977.

WRITINGS BY FRIEDKIN

Numbered Publications

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20 2 Publication list.
20 3-25 FB-360-06 1945 - 1975.
21 1-12 FB-360-07-09 1978 - 1986.
21 13 Unidentified negatives of figures, undated.
21 14 FB-282-10 Unidentified figures - Oversize drawings and photoreproductions, undated.
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21 15 Announcements - Miscellaneous, 1957 - 1985.
21 16 Studies of Photosynthesis with Isotopes (Denmark) - Lecture typescript with figures, 1949.
21 17 Desoxyranthosine - American Chemical Society (Chicago). Typescript, 1950.
21 18 Enzymatic Synthesis of Thymidine - Lecture schedule, manuscript, figures, and reprints of writings by others, 1951.
21 19 Synthesis of Thymidine - Manuscript, 1951.
21 20 Azguania Nucleosides - Paper presented at the Federation Meeting. Manuscript, 1952.
21 21 [Title unreadable] - Typescript, 1952.
21 22 Untitled - Atlantic City lecture. Manuscript with figures, 1962.
21 23 Biochemical Role of Vitamin B12 in Cellular Proliferation - Typescript of a lecture given by Friedkin at the IX Congresso da Sociedade Europeia de Hematologia, 1963.
21 24 Morris Friedkin, et. al. Two-Enzyme Screen for the Design of New Folate Antagonists - Typescript, ca. 1963.
21 25 Role of Folic Acid in Malaria - Manuscript and typescript, 1968.
21 26 Structure and Function of Microtubules (Harvard University) - Notecards, 1969.
21 27 Study of Folate Analogs (Faculty Seminar at UCSD) - Announcement and manuscript, 1970.
21 28 Untitled (Hadassah Medical School Seminar) - Manuscript, 1978.
21 29 Colchine Seminar - Manuscript, 1980.
21 30 Role of Microtubules - Announcement and manuscript, 1980.
21 31 Untitled lecture notes, ca. 1992.
21 32 Ancient History of Thymidylate Synthetase - Typescript, undated.
21 33 Use of Enzymens in the Design of New Drugs - Manuscript, undated.
21 34 Untitled lecture on cytoplasmic microtubules - Notecards, undated.

Unnumbered Publications and Unpublished Writings

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21 35-36 FB-360-10 Attempted Block of De Novo Serine Biosynthesis by Inhibition of Phosphoserine Phosphatase, 1983.
22 1 Morris Friedkin, et. al. Cell Cycle of L1210 Leukemia Cells is Blocked at G2/M by a Water-Soluable Polymer..., 1988.
22 2 CERDLIN Paper, 1987.
22 3 Class of 1968 - Tufts University School of Medicine Yearbook message, 1968.
22 4 Conservation of Form in Water, 1960.
22 5 Contrasting Styles with the Same Objective: Impressing Students with the Wonder of Life, 1975.
22 6 Crystalline Desoxyribose-1-Phosphate, ca. 1949.
22 7 Effects of 2micromolar Colchicine and 100 Ng/Ml Insulin on Cumulative Uridine Uptake, undated.
22 8 Forty Years - Manuscript of a timeline of Friedkin's major research interests, ca. 1982.
22 9 Friedkin, Morris, et. al. Tritium Isotope Effect During the Enzymic Synthesis of Thymidylate, ca. 1967.
22 10-12 FB-360-11 Friedkin, Morris and Leslie Wilson. Microtubule Theory of Memory, 1968.
22 13 New Genesis, 1971.
22 14 Pharmacology - Tufts University School of Medicine Yearbook message, 1961.
22 15 Preparation of Carbon-11 Labelled Thymidine, ca. 1962.
22 16 Morris Friedkin, et. al. Process for the Production of 5'-Deoxy-5-[18F] Fluoridine - Patent application and correspondence with Brookhaven National Laboratory, 1983.
22 17 Morris Friedkin and William Schwartz. Projection of Health Science Research Needs for the Tufts-New..., ca. 1958 - 1969.
22 18 Revolution in Pharmacology, 1960.
22 19 Morris Friedkin and Vincent Reid. Role of Folic Acid in Malaria, 1967.
22 20 Rolling in Something Ripe..., 1989.
22 21-23 FB-360-12 Studies on Aerobic Phosphorylation - Ph. D. dissertation, 1947 - 1948.
23 1 Suggestions for Noah Freidkin (son), 1988.
23 2 Two-Enzyme Screen for the Design of New Folate Antagonists, 1963.

TEACHING AND ADMINISTRATIVE MATERIALS

Washington University School of Medicine

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23 3 Relationship of Vitamin B12 and the Deoxyribosides - Manuscript of a lecture for a biochemistry seminar, 1949.
23 4 Quantitative Methods in Medicine - Course handouts, lecture manuscripts, examinations, and correspondence, 1950 - 1958.
23 5 Physiology Seminar, B12 and Intrinsic Factors - Notecards and lecture manuscript, 1951.
23 6 Washington University apartment lease, 1950.
23 7 New Cold Room at the Washington University School of Medicine, 1958.

Tufts University School of Medicine

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23 8 Elementary Statistical Analysis for Use in Pharmacology - Course handouts and lecture manuscripts, 1960.
23 9 Biology of Macromolecules Course: Learning and Memory - Lecture manuscript, reference list and reprints, 1966.
23 10 Introduction to Biochemistry - Course handouts and lecture manuscript, 1967.
23 11 Administrative documents - Includes Department of Pharmacology documents, Department of Biochemistry documents, A. Warren Stearns building information, and documents regarding Dean Haymen's retirement, 1958 - 1969.
23 12 Nine Good Years - This document is a collection of articles produced by members of the Department of Pharmacology at Tufts University School of Medicine during Friedkin's time as chair of the department, 1958 - 1967.
24 1-2 Yearbooks, 1961 - 1966.
24 3 Tufts-New England Medical Center - Newspaper clippings, 1966.
24 4 Yearbook, 1967.
Laboratory floor plans.
24 5 Includes Tufts University Department of Biochemistry floor plan, Tufts University Department of Pharmacology floor plan, and other unidentified floor plans, 1967.
24 6 MC-154-04 Includes Tufts University Department of Biochemistry floor plan, blueprint of floor plan for Tufts College Medical and Dental School (194?), and other unidentified laboratory or building floor plans, 1940 - 1967.

UCSD School of Medicine

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24 7 Chemistry 219, Folic Acid Lectures - Lecture manuscripts, lecture schedule, course handout, and examination, 1976.
24 8 Chemistry 269, Folic Acid Lectures - Lecture manuscripts, 1970.
24 9 Carbon Dioxide History for Introduction to Biochemistry 105R - Lecture manuscript, 1976 - 1978.
24 10 Suggestions for the Development of the Biomedical Program at San Diego - Manuscript, notes, correspondence, and newspaper clippings, 1964.
24 11 Provost of Revelle College - Includes notes, typescripts, and letters to parents from the Provost, 1974 - 1976.
24 12 Investigation of scientific misconduct - Includes Morris Friedkin and Suresh Subramani's notes on interviews with parties involved, photocopy of original complaint, correspondence and other related materials, 1992.
Restrictions Apply

WRITINGS BY OTHERS

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25 1 A - Z - Miscellaneous, 1936 - 1986.
25 2 Bobbs-Merrill Reprint Series in the Life Sciences, 1952 - 1963.
25 3 Drew, Ruth M. and Robert B. Painter. "Action of Tritiated Thymidine on the Clonal Growth of Mammalian Cells", 1958.
25 4 Dicker, Phillip and Enrique Rozengurt. "Synergistic Stimulation of Early Events and DNA Synthesis by...", undated.
Friedkin, Noah (son).
25 5 "Formal Theory of Social Control", undated.
25 6 "Horizons of Observability and the Limits of Informal Control in Intraorganizational...", 1983.
25 7 "On the Origins and Prevalence of the Incest Taboo", undated.
25 8 Hanke, Martin E. Laboratory and Classroom Outline for Hydrogen Ion and Oxidation-Reduction Potentials, 1939.
25 9 FB-360-13 Huang, Leaf and Richard E. Pagano. "Interaction of Phospholipid Vesicles with Cultured Mammalian Cells", 1975.
25 10 Hughes, W. L. "Chromosomal Replication and the Dynamics of Cellular Proliferation - Some Autoradiographic...", undated.
25 11 Levinson, Joel. "Photography of Anthony Friedkin", 1980.
25 12 Lomax, Nancita R. and V. L. Narayanan. "Chemical Structures of Interest to the Division of Cancer...", 1983.
25 13 Mackay, A. F. "Diazohydrocarbons", 1950.
25 14 Painter, R. B., et al. "Distribution of Tritium-labelled Thymidine in Escherichia Coli During Cell...", 1958.
25 15 Robertson, J. S. and W. L. Hughes. "Intra-Nuclear Irradiation with Tritium-labeled Thymidine", undated.
25 16 Sreevalson, T., et al. "Differential Effect of Interferon on DNA Synthesis 2-deoxyglucose Uptake and...", undated.
25 17 Wilson, Leslie. "Grasshopper Nueroblast Report.", 1965.
25 18 Yorek, Mark A., et al. "Effect of Ethanolamine on Choline Uptake and Incorporation into...", undated.

MISCELLANEOUS MATERIALS

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25 19 IX Congresso da Sociedade Europeia de Hematologia - Conference program, correspondence and notes, 1963.
25 20 CERDLIN - A Potential Cancer Chemotherapeutic Agent Derived from Commercial Dowx 50 (Cation Exchange Resin) - Record of invention and correspondence, 1986 - 1987.
25 21 Gordon Research Conferences - Includes conference booklets with notes, 1966 - 1968.
25 22 International Convention of Biochemists (Bangalore) - Correspondence, convention materials and abstract of folic acid in malaria research, 1967.
26 1 Malaria Conference (Walter Reed Army Institute of Research) - Correspondence, conference schedule and notes taken by Friedkin at the conference, 1968.
26 2 Kaplan, Nathan O. Memorial materials - Correspondence and reprints of memorial articles from Analytical Chemistry, 1986 - 1987.
26 3 Minutes of the Screening Committee for the California Division (American Cancer Society), 1978.
26 4 Newspaper clippings concerning others, 1965 - 1986.
26 5 Oregon State Seminar - Notes and correspondence, 1973.
26 6 Review of Graduate Pharmacology Program at the University of California, San Francisco - Correspondence, program guides and typescripts of review, 1989.
26 7 Seventh International Congress of Biochemistry (Tokyo) - Correspondence and conference schedule, 1967.
26 8 Slides - Miscellaneous, undated.
26 9 Vietnam - Correspondence, 1966.

ORIGINALS OF PRESERVATION PHOTOCOPIES

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26 10 Originals of preservation photocopies.


Finding aid generated: 2012-07-17