Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery
Ji-Ho Park, Geoffrey von Maltzahn, Erkki Ruoslahti, Prof., Sangeeta N. Bhatia, Prof., Michael J. Sailor, Prof.
Angewandte Chemie, International Edition 47(38):7284-7288
UCSD Materials Science & Engineering, Department of Chemistry & Biochemistry
From the UCSD press release, Researchers Develop Nano-Sized ‘Cargo Ships’ to Target and Destroy Tumors:
Scientists have developed nanometer-sized ‘cargo ships’ that can sail throughout the body via the bloodstream without immediate detection from the body’s immune radar system and ferry their cargo of anti-cancer drugs and markers into tumors that might otherwise go untreated or undetected.
“The idea involves encapsulating imaging agents and drugs into a protective ‘mother ship’ that evades the natural processes that normally would remove these payloads if they were unprotected,” said Michael Sailor, a professor of chemistry and biochemistry at UCSD who headed the team of chemists, biologists and engineers that turned the fanciful concept into reality. “These mother ships are only 50 nanometers in diameter, or 1,000 times smaller than the diameter of a human hair, and are equipped with an array of molecules on their surfaces that enable them to find and penetrate tumor cells in the body.”
There’s also a movie!
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